| Description | Human Trabecular Meshwork Cells (HTMC) are endothelial-like cells in the spongy connective tissue located in the front of the eye. HTMC forms a layer of beams and is a part of the fibrous basement membrane that contains the extracellular matrix and cells. In areas of high outflow resistance, HTMC regulates the intraocular pressure by controlling the drainage of fluid into the tube that flows into the blood. Changes in HTMC contractility and tension mediate outflow. Due to its phagocytosis, HTMC can also be used as a self-cleaning filter. Live cell imaging of the cytoskeleton provides valuable information for actin dynamics in HTMC. Other research aims to identify treatments that relax HTMC contractions to increase fluid outflow and reduce intraocular pressure. The specific targeting effect of HTMC can also play a clinical role by increasing the therapeutic efficacy of nanoparticles for gene delivery. |
| Size/Quantity | T-25 Flask/T-75 Flask/24 well/96 Well |
| Quality Control | No bacteria, yeast, fungi, mycoplasma |
| Application | For research use only |
| Tissue | Normal healthy human adult eyes |
| Character | Positive for Fibronectin |
| Bioassay | Attach, spread, proliferate in Growth Med |
| Cryovial | ~500,000 HTMC (1st passage) in Freezing Medium w/ 10% FBS, 10% DMSO |
| Kit | Cryovial frozen HTMC, Growth Medium (631-500), Subculture Rgnt Kit (090K) |
| Proliferating | Shipped in HTMC Growth Medium, psg 2, flasks or plates |
| Doublings | At least 12 |
| Price | Inquiry |
