| Description | C-X-C Motif Chemokine Receptor 4 |
| Category | Protein Coding |
| GIFtS | 50 |
| GC id | GC02M136114 |
| Score | 29.42 |
| Entrez Gene Summary | This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| GeneCards Summary | CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome 1 and Macroglobulinemia. Among its related pathways are Peptide ligand-binding receptors and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is CXCR2. |
| Gene Database | GeneCards: The Human Gene Database |
| Price | Inquiry |
