Cat. No.: GENE0005

IL10

Description Interleukin 10
Category Protein Coding
GIFtS 46
GC id GC01M206767
Score 42.30
Entrez Gene Summary The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
GeneCards Summary IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are ERK Signaling and Immune response IFN alpha/beta signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-10 receptor binding. An important paralog of this gene is IL20.
Gene Database GeneCards: The Human Gene Database
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