| Description | Insulin |
| Category | Protein Coding |
| GIFtS | 46 |
| GC id | GC11M002159 |
| Score | 31.49 |
| Entrez Gene Summary | This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020] |
| GeneCards Summary | INS (Insulin) is a Protein Coding gene. Diseases associated with INS include Maturity-Onset Diabetes Of The Young, Type 10 and Hyperproinsulinemia. Among its related pathways are Transport to the Golgi and subsequent modification and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding. An important paralog of this gene is INS-IGF2. |
| Gene Database | GeneCards: The Human Gene Database |
| Price | Inquiry |
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